Formulation And Evaluation Of Vaginal Drug Delivery System Of Tenofovir: An Experimental Study

Abstract

ABSTRACT Background: Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) pose significant worldwide challenges. Low oral bioavailability of antiretroviral s ( AntiRV), hinders their effectiveness in reaching infection sites and increasing the risk of relapse. Preventative measures like topical vaginal pre exposure prophylaxis (PrEP) are crucial in reducing HIV transmission for HIV negative individuals to lower their virus contraction risk during intercourse. Objectives: The first part of the project aimed to design and develop novel PrEP sispersible vaginal tablets ( DT composed of tenofovir disoproxil fumarate TDF loaded bio adhesive chitosan microparticles (T CM). The second part focused on formulating pessaries with TDF loaded bio adhesive sodium alginate ( S Alg ) microspheres (T AM) for intra vaginal administration to address the shortcomings associated with conventional oral dosage forms.