Comparison of effect of intravenous esmolol and preservative free lidocaine in attenuation of hemodynamic response to extubation in elective surgeries under general anesthesia – a one year hospital based single blinded randomized clinical trial

Abstract

Background: Endotracheal extubation is an unpredictable and tricky part of anaesthetic management and can be associated with detrimental airway and hemodynamic responses. Elevation in blood pressure and heart rate during extubation is brief but may have detrimental effects. Hence there should be an effective means of attenuating sympathetic responses to extubation. Many drugs have been used to attenuate extubation response such as IV diltiazem, propofol, verapamil, dexmedetomidine. However, there has been no study comparing the effects of IV esmolol and IV preservative free lignocaine in attenuating the stressor response during extubation.