Comparison of two different doses of dexmedetomidine In attenuation of sevoflurane associated emergence Agitation in paediatric patients, posted for lower Abdominal surgeries –a hospital based, randomized Controlled trial.

Abstract

BACKGROUND: Emergence Agitation (EA) is a very common immediate postoperative complication encountered in paediatric population undergoing anaesthesia with Sevoflurane. Owing to its low blood solubility and rapid recovery, Sevoflurane is the best inhalational agent for use in paediatric age group. But its disadvantage of causing agitation is distressing to the anaesthesiologists. Dexmedetomidine is found to reduce the incidence of EA. Fewer studies have been done comparing the effects of particularly two doses (0.3 mcg/kg and 0.5 mcg/kg) of Dexmedetomidine. Hence this study was designed to compare the effectiveness of these two doses in reducing EA in children. AIM: To assess the effectiveness of two different doses of Dexmedetomidine 0.3 mcg/kg IV and 0.5 mcg/kg IV, given intraoperatively in reducing postop EA along with the changes in hemodynamic parameters after drug administration.