Study of effect of intranasal Dexmedetomidine on stress response to Pneumoperitoneum in laparoscopic surgeries: a One year double blinded hospital based Randomised clinical trial

Abstract

Background: Insufflation in laparoscopic surgeries may cause sympathetic stimulation, which can cause tachycardia and hypertension. Dexmedetomidine, a potent alpha-2 adrenoceptor agonist is gaining popularity to abolish this pressor response. This study explores the effect of intranasally used dexmedetomidine on stress response to pneumoperitoneum. Aims and Objectives: To determine the effect of intranasal dexmedetomidine on stress response to pneumoperitoneum in laparoscopic surgeries and to determine the side effects of the study drug if any.