An interventional study comparing Intralesional verapamil and Intralesional triamcinolone acetonide In the treatment of keloids in a Tertiary care hospital

Abstract

ABSTRACT · Background: Keloids is caused by abnormal hyperproliferation of dermal fibroblast, causing expansion beyond boundaries of insult. Intralesional (IL) triamcinolone acetonide (TAC) causes inhibition of fibroblast. Intralesional verapamil, a calcium channel blocker activates procollagenase causing depolymerization of actin, inhibiting incorporation of proline and slowing action potential by which it reduces pain and pruritis associated with keloids. This study compares both the modalities for treatment of keloids. · Aims and Objectives: To assess and compare the efficacy, safety, reduction in pain and pruritis and side effects between intralesional verapamil hydrochloride and triamcinolone acetonide in treatment of keloid in patient aged 18 to 70 years.