Study of immature granulocyte count as early diagnostic marker to differentiate between sirs and sepsis patients

Abstract

Introduction: Differentiation between Systemic Inflammatory Response Syndrome (SIRS) and sepsis at earliest remains challenging but crucial for optimal patient outcomes. Traditional markers like serum Pro-calcitonin, blood cultures etc lack the necessary sensitivity and specificity for early diagnosis. This study investigated the utility of immature granulocyte (IG) count. Methodology: A prospective study was conducted on 65 patients presenting with SIRS criteria. According to established criteria patients were categorized into SIRS and sepsis groups. Demographic data, clinical parameters, and laboratory values including IG count, total leucocyte count, bilirubin, and creatinine were analyzed. The diagnostic performance of IG count was evaluated using various cut-off values.