Preoperative Intravenous Vs Combined Intravenous Plus Intra-Incisional Antibiotic Administration In The Prevention Of Surgical Site Infections

Abstract

ABSTRACT Background: Surgical Site Infections (SSIs) are among the most common healthcareassociated infections, contributing significantly to morbidity, prolonged hospitalization, and increased healthcare costs. Despite advancements in preoperative prophylaxis, SSI rates remain high, especially in abdominal surgeries. The use of intra-incisional antibiotic administration, in addition to conventional intravenous (IV) prophylaxis, has emerged as a potential strategy to reduce the risk of postoperative infections. This study evaluates the efficacy of combining preoperative intraincisional and intravenous antibiotic administration in preventing SSIs in clean abdominal surgeries, particularly hernia repairs. Objectives: The primary objective of this study is to determine the impact of preoperative intra-incisional antibiotic administration in conjunction with intravenous prophylaxis in reducing SSIs. Secondary objectives include comparing the efficacy of combined IV and intra-incisional antibiotic administration with IV antibiotics alone and assessing associated risk factors influencing infection rates.