Comparing The Efficacy of Topical Timolol vs Amorphous hydrogel and silver colloid dressing in Chronic Diabetic Foot Ulcers: a Randomized Controlled Trial.

Abstract

STRUCTURED ABSTRACT Background: Diabetic Foot Ulcers (DFUs) are a major complication of Diabetes Mellitus (DM), resulting from a combination of neuropathy, peripheral arterial disease (PAD), and poor glycemic control. DFUs are a leading cause of lower limb amputations, contributing to increased morbidity and healthcare costs. Proper wound healing requires moisture retention, infection control, and vascularization, leading to the exploration of novel treatments such as topical Timolol maleate, hydrogel dressings, and silver colloid gel. Objectives: This study aims to compare the efficacy of topical Timolol maleate (0.5%) with Amorphous hydrogel and silver colloid dressing gel in chronic DFU management. It also evaluates the safety profile of topical Timolol and its impact on wound healing rates after two weeks of treatment.