Evaluation of postoperative pain following Preemptive analgesia with iv paracetamol in Unilateral lichtenstein’s inguinal hernia Surgery, randomized, control trial

Abstract

Introduction: Pain from surgical procedures is due to tissue trauma, through activation of nociceptive receptors which causes acute pain and long-term pain (central sensitization), which may cause physical, cognitive and emotional discomfort. Pre-emptive analgesia refers to the administration of pain-relieving treatments before surgery to prevent the onset of central sensitization caused by the incisional and inflammatory injuries that occur during and after surgery. By intervening before the surgical trauma, pre-emptive analgesia aims to reduce immediate postoperative pain and decrease the likelihood of developing chronic pain by lessening the altered processing of sensory input in the central nervous system. IV paracetamol is widely used as a first-line analgesic and antipyretic treatment for pain management in both adults and children. It is the most commonly used drug for postoperative pain management. In proper dosage it is the safest drug with minimal adverse effects. It can be given in patients with diabetes, hypertension, chronic kidney disease and other comorbidities with minimal to no risk. IV PARACETAMOL if given as PRE-EMPTIVE ANALGESIA can cover a better range of patients, patients with known comorbidities and can reduce the immediate post surgery pain and therefore the need for administering rescue analgesia along with preventing the possibility of development of chronic pain in patients who are undergoing open inguinal hernia mesh repair surgery(49,56)