Clinicopathological correlation of Alpha-methylacyl -coenzyme a Racemase expression in colorectal Neoplasia- a cross-sectional study in a Tertiary care hospital

Abstract

BACKGROUND: Colorectal neoplasia incorporates a variety of lesions ranging from benign adenomatous polyps to malignant colorectal carcinomas (CRC), collectively posing a substantial burden on global public health. Recent studies have shown dysregulated expression of Alpha-methyl acyl-coenzyme a racemase (AMACR) in various carcinomas like colorectal carcinoma, hepatocellular carcinoma, renal cell carcinoma, and prostatic carcinoma. Owing to its tumor heterogeneity, a comprehensive understanding of the clinicopathological correlation of AMACR expression in colorectal neoplasia is essential to unravel its true diagnostic and prognostic potential. OBJECTIVES: This study aimed to analyse clinicopathological correlation of alpha methyl acyl-coenzyme- a racemase expression with colorectal neoplasia.