efficacy of topical statin medication on diabetic foot ulcer wound healing dynamics- a randomized controlled trial for period of one year

Abstract

DM is a widespread, non-communicable disease seen among world population.1Amongst the complication of DM, DFU is seen quite often. Diabetic foot disorders consists of the ulcers over the foot related with infection, PAD and neuropathy. It is a noteworthy reason for lower extremity amputation. Infection of DFU is one among the common complications seen in DM patients. One of the major problem in health sector is antibiotic resistance. Increasing antibiotic resistance has restricted the use of systemic antibiotics. In this situation topical antiseptics with broad spectrum of activity and minimal or no resistance plays an important role in management of infected ulcers. One of the newer modalities for wound healing are topical statins that have been conventionally used for treatment against hyperlipidemia. Statins can facilitate healing of ulcers because of their wide spectrum of effects comprising of immunomodulatory, antioxidative, anti-inflammatory, antibacterial actions as well as enhancement of vascular function. Most of the studies done to evaluate the results of topical statin therapy on diabetic wounds, have been executed over animal and invitro human tissue. The lack of clinical studiesalongwith the need to explore the potential of topical statins in treating diabetic foot ulcers made us to compare healing of diabetic foot ulcers, between topical atorvastatin with saline and saline dressing alone