Comparison of hyaluronate-iodine and ornidazole complex woundgel dressing versus povidone-iodine dressing in healing of chronic diabetic foot ulcers- a randomised controlled trial for a period of one year

Abstract

Comparison of hyaluronate-iodine and ornidazole complex wound gel dressing versus povidone iodine dressing in healing of chronic diabetic foot ulcers- A randomised controlled trial for a period of one year. Back ground Diabetes mellitus is a metabolic disorder characterized by increased glucose levels in the body, which can be caused by reduced secretion of insulin, decreased utilization of glucose or increased production of glucose.1Amongst the complications of diabetes mellitus, diabetic foot ulcer is one of the most frequently seen complication. Wound care has an important role in diabetic foot ulcer management, that involves aseptic cleansing of the ulcer and application of a dressing that can promote an optimum wound healing environment.5 Hyaluronan, one of the recent discoveries in the field of wound dressings has properties such as preserving tissue integrity, lubrication, and water absorption. Hyaluronic acid stimulates migration of mesenchymal and epithelial cells and differentiation, eventually improving deposition of collagen and angiogenesis for wound repair.9Because of these specific characters of hyaluronic acid, fortification of ornidazole and povidone iodine in the wound gel and very few clinical studies in the literature prompted us to compare healing of diabetic foot ulcers, between hyaluronate-iodine and ornidazole complex wound gel and povidone iodine dressings.