Evaluation of wound healing and bone regeneration using topical combined application of vitamin c, dexamethasone and beta-sodium glycerophosphate for healing of extraction socket- a comparative study

Abstract

In the first three months after extraction, the bone loss is substantial and can result in both hard and soft tissue defects affecting the potential of the site to regenerate with an adequate amount of bone. This bone loss accounts for the reduced vertical as well as horizontal dimension of alveolar bone decreasing the quality of bone available for rehabilitation. Nowadays, autogenic bone graft is gold standard and is used commonly among Oral and Maxillofacial surgeons. Numerous researchers and clinicians have developed over time different socket preservation materials, which have their pros and cons like problem of supply, complex surgical procedure, risk of contamination and high cost. This study aims to evaluate the efficacy of osteogenic inducer (Beta-Sodium Glycerophosphate + Vitamin C + Dexamethasone) when placed in the extraction socket and also to assess the potential use of the material for better wound healing in humans as this combination has successfully been used in rabbits and on human bone marrow cells as an in-vitro study.