Comparison Of Onset And Duration Of Sensory And Motor Blockade With Intrathecal Isobaric Ropivacaine Versus Isobaric Ropivacaine-Clonidine For Infraumbilical Surgeries - A One Year Hospital Based Randomised Control Trial

Abstract

Background and Objective ABSTRACT Spinal anaesthesia remains a popular technique used for surgeries involving abdomen and lower limbs providing fast onset and effective sensory and motor blockade. Clonidine a potent alpha 2 agonist is commonly used adjuvant. The present study was done to evaluate onset and duration of sensory and motor block with isobaric 0.75 % ropivacaine and 0.75 % isobaric ropivacaine with 15 mcg clonidine as an adjuvant. Methods This one year randomized controlled trial was conducted in the Department of Anaesthesiology, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum during the period of January 2012 to December 2012. A total of 70 patients undergoing infra umbilical surgeries were allocated into two groups namely, Group I ( n=35; Patients received 3 ml of isobaric 0.75 % ropivacaine intrathecally ) or Group II ( n=35; Patients received 3 ml of isobaric 0.75 % ropivacaine + 15 mcg of clonidine intrathecally ) . Results In this study, demographic parameters were comparable in both the groups. Onset of sensory block was comparable in both the groups but duration of sensory block was prolonged in group II ( 191.7±19.21 minutes) than in group I ( 180.8 ±13.08 minutes) . Onset of motor block was faster in group II ( 11.4±2.29 minutes ) than in group I ( 13.6±2.29 minutes) . Duration of motor block was prolonged in group II ( 271.3±18.32 minutes) than from group I ( 224.5±16.46 minutes) . Mean heart rate VI was significantly lower in group II than in group I. Mean arterial pressure was comparable in most of the recordings between both the groups. Conclusion and interpretation Overall, based on the findings of this study it may be concluded that, addition of clonidine to 0.75 % isobaric ropivacaine intrathecally prolonged the duration of sensory and motor block but with no effect on sensory onset but faster onset of motor block with no significant hemodynamic changes.