To Compare The Efficacy Of Recombinant Human Platelet Derived Growth Factor Dressing Versus Normal Saline Dressing In Wound Reduction In Patients With Chronic Diabetic Foot Ulcer: A Randomized Controlled Trial

Abstract

Background ABSTRACT The incidence of diabetes and its complications are on a rise, the risk of lower extremity amputations is 15 fold higher in diabetics as compared to non-diabetics. Chronic diabetic foot ulcer is the leading cause of amputations in these patients. These diabetic ulcers are known to be resistant to conventional treatment and may herald severe complications if not treated wisely. Platelet-derived growth factor ( PDGF ) is one of the numerous growth factors plays a significant role in angiogenesis. Objective of the study To compare the efficacy of topically applied recombinant human Platelet Derived Growth Factor ( rh-PDGF ) in chronic diabetic foot ulcer. Methodology The present study was a randomized controlled conducted at KLESH Prabakar Kore Hospital and MRC Belgaum. Total of 80 patients were assigned. They were grouped through computerized randomization into two. Control group patients were treated with conventional dressing and study group patients were treated with rh-PDGF dressing and observed for reduction in the wound size in a span of 15 days. Results The study group patients showed higher reduction in wound size of about 39.55% as against 11.79% of the control group with P value at 0.001. . Conclusion Topical application of 100µg/g of rh-PDGF once daily significantly increases incidence of wound healing in chronic diabetic foot ulcers.