To Study Euphorbia Prostrata Dry Plant Extract Vs Micronised Purified Flavonoid Fraction Of Diosmin Effectiveness In Treatment Of Bleeding Haemorrhoids In Patients Attending A Tertiary Care Hospital – A Randomised Control Study

Abstract

Background and Objectives Hemorrhoids are one of the most frequent anorectal disorders encountered in the primary care sitting. The present study was aimed to assess the effectiveness of Euphorbia Prostrata dry extract in comparison with micronized purified flavonoid fraction of diosmin in control of bleeding haemorrhoids and to find the safety of Euphorbia Prostrata dry extract. Methodology This one year single blind randomized controlled trial was conducted in the Department of General Surgery, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum. A total of 60 patients divided into two groups of 30 each as experimental or control group randomly by envelop method that is Group E (euphorbia prostrate) and Group C (diosmin) respectively. Results In the present study, the male female ratio in group E was 4:1 while in group C it was 14:1. The mean age in group E was 39.60±6.52 years compared to 43.40±10.11 years in group C (p=0.092). The mean duration of bleeding in group E was 14.6±5.41 days compared to 12.4±4.89 days in group C (p=0.109). During fifth day follow up, significantly higher number of patients in group E (53.33%) reported average reduction of bleeding compared to group C (13.33%) (p=0.001). At second and third follow up, both the groups were comparable and no statistically significant difference was noted with relief from pruritis at all the follow ups. Conclusion and interpretation Overall, treatment of euphorbia prostata significantly resulted in faster recovery from bleeding at first follow up on day five but further its was comparable with micronized purified flavonoid fraction of diosmin. The safety of Euphorbia Prostrata dry was comparable with micronized purified flavonoid fraction of diosmin.