A Cross Sectional Study Of Serum Lipid Profile In 40 Patients Of Psoriasis And Equal Number Of Age And Gender Matched Controls

Abstract

BACKGROUND ABSTRACT Psoriasis is a chronic inflammatory skin disease that is associated with an increased cardiovascular risk profile. The underlying pathogenic mechanisms remain unclear. Multiple factors including systemic inflammation, oxidative stress, aberrant lipid profile and concomitant cardiovascular risk factors have been associated. Psoriasis has been associated with abnormal plasma lipid metabolism and oxidative stress. OBJECTIVES 1. To determine the serum lipid disturbances in psoriasis 2. To study the demographic and clinical data in psoriasis METHODS The study was conducted at Dr. Prabhakar Kore KLE Hospital and MRC, Belgaum. Forty subjects, of psoriasis in the age group of 20-70 years were considered as cases. Forty healthy subjects of comparable age and sex were chosen as controls. Cases with history of diabetes, hypertension, obesity, family history of hyperlipidemia, intake of systemic drugs like lipid lowering agents, alcohol and smoking were excluded from the study. COLLECTION OF DATA Blood and urine samples were collected after obtaining proper consent from all cases and controls. Serum lipids were measured by enzymatic methods. Serum VI fasting blood sugar, blood urea, serum creatinine, urine sugar and proteins were also measured simultaneously using routine laboratory methods. RESULTS Serum TC, LDL-C, TC/HDL-C ratio and LDL-C/HDL-C ratio were significantly higher in psoriasis patients compared to controls. There was no statistically significant difference in serum TG, HDL-C and VLDL-C among cases and controls. CONCLUSION The psoriatic patients could be considered as a group with increased atherosclerotic risk because of susceptibility to lipid profile, lipoprotein content and increased oxidative stress. Dyslipidemia may be a factor contributing to increased coronary heart disease in patients with psoriasis. A pathogenic link may coexist between lipoprotein, oxidative stress and psoriatic pathophysiology. This provides valuable information for timely intervention.