Clinical Profile of Patients with Ulcerative Colitis”- one Year Cross Sectional Study at KLES Dr. Prabhakar Kore Hospital & MRC, Belgaum

Abstract

Background and Objectives ABSTRACT The two major forms of inflammatory bowel disease are Crohn’s disease ( CD ) and ulcerative colitis ( UC ) . Crohn’s disease can affect any part of GIT and UC affects only large bowel. Both these conditions are not associated with increased mortality. The objectives of the present study were to assess the clinical profile of ulcerative colitis. Methods The present One year cross sectional study was conducted in the Department of General Medicine on 35 patients of UC admitted in KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum between the period of January 2008 to December 2008. Patients underwent thorough clinical examination according to predesinged and pretested proforma, colonoscopy and biopsy which were supported by relevant investigations. All patients in the study underwent endoscopy. Assessment of clinical disease activity in patients of UC was done by Truelove and Witts index. Results Present study revealed peak incidence in age group of 21 to 40 years. Male:Female ratio was 1.91:1 revealing higher male predominance. Diarrhea ( 100% ) with passage of blood in stools ( 97.14% ) and pain in abdomen ( 68.57% ) were common presenting complaints. Extraintestinal manifestations are seen in moderate to severe disease group in about 25.71% of patients, arthritis is most IX common extraintestinal manifestation. Ulcerative colitis was more common in non smokers. Nearly two third of the patients have left sided disease or pancolitis. Conclusion There is significant correlation between clinical severity and histopathological grading. There is significant correlation between endoscopic grading and histopathological grading. There is no correlation of endoscopic grading ( Baron’s criteria ) with clinical severity ( Truelove Witts) . The disease causes substantial morbidity and health care cost.