A Cross Sectional Study to Know the Prevalence of Insulin Resistance Among Hypertensive Patients Attending KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum

Abstract

Background and objectives ABSTRACT It is estimated that at least 50% of hypertensive patients are insulin resistant, and insulin resistance ( IR ) is the fundamental abnormality in the pathogenesis of the cardiometabolic syndrome. The present study was undertaken, to know the prevalence of IR in hypertensive individuals. Methodology The present one year cross sectional study was conducted in the Department of Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum on non diabetic hypertensive patients during the period from January 2009 to December 2009. A total of 65 hypertensive patients were studied. Investigations like FBS and PPBS, lipid profile and ECG were done. Fasting insulin levels were measured by MEIA method and insulin resistance was calculated by homeostasis model for assessment of IR. Insulin resistance was defined as HOMA IR more than 3.8. Results In this study males ( 76.92% ) outnumbered females. Majority ( 50.77% ) of the patients, were in the age group of 51 to 60 years and 47.69% had three to six years duration of hypertension. Majority ( 70.77% ) of the patients were on ACE inhibitors or ARBs. The prevalence of IR in this study was 41.54% ( HOMA IR > 3.8) . Majority ( 74.08% ) of the patients with IR were aged more than 51 years. In patients on ACE inhibitors or ARBs, IR was less ( 51.85% ) as compared to beta blockers ( 66.67% ) . In patients with IR, history of CVA was seen in 18.52% and VI IHD was noted in 48.15%. Among patients with IR, history of smoking and alcohol consumption was seen in 48.15% and 11.11% respectively. Linear relation between IR and BMI was apparent till the value of 29.9 Kg/m beyond. Abnormal WHR was noted in 19 ( 70.37% ) patients with HOMA IR more than 3.8. Interpretation and conclusion The prevalence of insulin resistance in hypertensive non diabetic patients was 41.54%. Insulin resistance increased with advancing age, duration of hypertension and obesity.