A Cross Sectional Study to Find the Association Between Prolonged QT Interval and Microalbuminuria in Patients of Type 2 Diabetes Mellitus

Abstract

Background and objectives ABSTRACT The link between microalbuminuria and premature death in type 2 diabetes is not completely explained by conventional cardiovascular risk factors. CAN is associated with a high mortality which is attributed not only to sudden death but also to diabetic nephropathy. Prolonged QT c interval is found to be a specific indicator for CAN. The objective of the present study was to find the association between prolonged QT diabetes patients. Methodology c interval and microalbuminuria in type 2 The present one year cross-sectional study was conducted in the Department of Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum on 86 patients ( 43 with normoalbuminuria and 43 with microalbuminuria ) with type 2 DM during the period of January 2009 to December 2009. Investigations like complete blood count, erythrocyte sedimentation rate, urine routine and microscopy, FBS or PPBS or RBS were done. Urine albumin excretion test and ECG was done. QTc interval was calculated using Bazzet’s formula. Results In the present study, 60.47% and 69.77% were males in normoalbuminuric and microalbuminuric groups respectively. The mean age in normoalbuminuric group was 54.51±10.15 years and it was 55.93±11.73 years in microalbuminuric group. Most of subjects had duration of diabetes less than 10 V years ( 44.19% in normoalbuminuric and 34.88% in microalbuminuric groups respectively ) . QTc interval was significantly prolonged in 25.58% of patients in normoalbuminuric and 69.77% in microalbuminuric group ( p=0.001) . Mean QTc interval was significantly more ( 454.73±29.33 ms) in microalbuminuric group compared to normoalbuminuric group ( 418.13±27.44 ms) ( p=0.001 ) . Mean duration of diabetes was less ( 14.93±3.81 years) in microalbuminuric group compared to ( 16.00±4.87 years) normoalbuminuric group. Interpretation and conclusion Prevalence CAN as diagnosed by prolonged QTc interval was more in Type 2 DM patients with microalbuminuria and these patients can develop CAN with short duration of diabetes.