Factor Viii: C Levels And Macrovascular Complications In Diabetes Mellitus

Abstract

Background and objectives ABSTRACT The plasma levels of many clotting factors, including fibrinogen, factor VII, factor VIII:C, factor XI, factor XII, kallikrein and von Willebrand factor, are elevated in diabetes. The present study was undertaken to determine plasma activity of factor VIII:C in diabetics, with and without macrovascular complications. Methodology The present one year case control study was conducted in the Department of Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum from January 2011 to December 2011. A total 50 patients that is, 25 patients with DM but without macrovascular complications were enrolled in group B and 25 patients with DM and macrovascular complications were enrolled in group C. These patients were compared with 25 age matched individuals with no specific illness and who were non-diabetic ( group A ) . Results In the present study the male to female ratio in group A, B and C was 3.16:1, 2.12:1 and 1.5:1 respectively. The mean age in group A was 55.20 ± 9.15 years. Similarly in group B the mean age was 55.44 ± 7.74 years and group C it was 55.40 ± 6.44 years ( p>0.05) . The factor VIII:C was significant raised in 56% of patients in group B and 88% of patients in group C compared to 12% in group A ( p< 0.001 ) . The mean factor VIII:C levels in group C were significantly high V ( 256.80±49.38) compared to group B ( 179.52±46.37) and group A ( 111.57±25.48) ( p=0.001 ) . Conclusion and interpretation The plasma activity of factor VIII:C was significantly high in diabetics with and without macrovascular complications when compared with healthy age matched controls. Within the diabetic subgroup, patients with macrovascular complications had significantly higher factor VIII:C levels compared to those without complications.