Study Of Insulin Resistance And Inflammation In Relation To Various Degrees Of Blood Pressures In Adults – A One Year Cross Sectional Study

Abstract

Background and objectives ABSTRACT There has been increasing number of evidences connecting insulin resistance to future cardiovascular events in hypertensives suggesting that insulin resistance is the basis for the so called metabolic syndrome irrespective of diabetic status. The present study was aimed to assess the insulin resistance and inflammation in relation to various degrees of blood pressures in non diabetic adults and to evaluate insulin resistance as a marker of inflammation. Methodology The present one year cross sectional study was conducted in the Department of Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum from January 2011 to December 2011 on a total of 180 patients divided into three groups of 60 each namely, normotensives, prehypertensives and hypertensives. Results In this study male preponderance was seen in all three study groups ( 76.67% in normotensives, 73.33% in prehypertensives and 75% in Hypertensives) . Among normotensives equal distribution of age was observed whereas, among prehypertensives 61.67% and among hypertensives 63.33% had age from 46 to 60 years. The mean age among normotensives, prehypertensives and hypertensives was 48.40±15.38, 53.03±10.86 and 50.76±8.05 years respectively. Highest HOMA index among hypertensives ( 4.59±1.87 ) compared to prehypertensives ( 2.91±1.27 ) and normotensives ( 2.17±0.66 ) . V Conclusion and interpretation Waist circumference and total cholesterol showed significant positive correlation with HOMA index in all the three groups that is, normotensives, prehypertensive and hypertensives whereas, serum LDL and TG positively correlated with HOMA in all three groups but correlation was statistically significant in prehypertensives only. Serum HDL showed negative correlation with HOMA index in all three groups but statistically significant only in prehypertensive population. hs-CRP showed statistically significant positive correlation with HOMA index in all three groups that is normotensives, prehypertensive and hypertensive.