Estimation Of Levels Of Vitamin D In Type 2 Diabetes Mellitus - One Year Cross-Sectional Study

Abstract

Background and objectives Recently, Vitamin D has sparked widespread interest in the pathogenesis and prevention of diabetes. The present study was undertaken to estimate the levels of Vitamin D in patients with Type 2 Diabetes Mellitus and to correlate levels of Vitamin D with Glycemic status of Diabetes Mellitus. Methodology The present one year cross sectional study was carried out in the Department of Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum from January 2012 to December 2012. A total of 100 patients with type 2 diabetes mellitus were studied. The estimation of Vitamin D was done using Siemens, ADVIA Centraur VitD assay, a one pass 18 minute antibody competitive immunoassay. Results Maximum number of cases were in the age group of 51 to 60 that is 32 patients (32%). The mean age of study population was 60.6 ± 11.28 years. Out of 100 patients, 62 (62%) were males and 38 patients (38%) were females, with a ratio of male to female 1.63:1. In more than 87 patients (87%), the levels of Vitamin-D were below normal, in 7 patients (7%) the levels were insufficient and in remaining 6 patients (6%) the levels were either normal or more than normal. Most of the patients had fasting and post prandial glucose abnormality (98% each) and HOMA-IR was >3.8 in 60 patients (60%). Conclusion and interpretation The results observed were a significant correlation of Vitamin-D levels with variable factors – post-prandial blood sugar, HbA1c, HOMA-IR, cholesterol and low density lipoprotein (LDL). However, we did not find significant correlation with variable factors – age, gender, duration, body mass index, fasting blood sugar, high density lipoprotein (HDL) and triglycerides.