Correlation Of Serum Uric Acid Levels & Lipid Levels In Patients With Ischaemic Cerebrovascular Accident - A One Year Cross Sectional Study

Abstract

Background and objectives Stroke is the third common cause of death in the world after coronary heart disease and cancer. The present study was aimed to assess serum uric acid levels in patients with ischemic cerebrovascular accident, its utility as a prognostic marker and to correlate between serum uric acid levels and lipids in patients with ischemic cerebrovascular accident. Methodology This study was conducted on a total of 100 patients with ischemic cerebrovascular accident from January 2012 to December 2012 at Department of Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum. Uric acid level was measured with photometry using the diagnostic kit for quantification of uric acid prepared by ELITech Clinical Systems. Results In this study 54% of the patients were females compared 46% males with male to female ratio of 1.1:1. The commonest age group was more than 60 years present in 41% of patients. The history of hypertension and diabetes was present in 59% and 30% and smoking and alcohol consumption was noted in 51% and 32% respectively. Of the 54 women history of menopause was reported by 40 patients. Very severe NHSS score were noted in 18% patients. Serum creatinine was raised in 14% of the patients. Lipids, viz. cholesterol, HDL, LDL and triglycerides were abnormal in 83%, 86%, 52% and 80% respectively. Raised serum uric acid levels were noted in 69% of the patients and the mean serum uric acids levels were 7.72 ± 1.22. Conclusion and interpretation Serum uric acid levels in patients with acute ischemic stroke are on the higher side. Higher serum uric acid levels were consistently found in patients with very severe and severe ischemic stroke assessed by NIHS score. Stroke mortality in our study was significantly correlated with high serum uric acid levels. Positive association was found between raised serum uric acid levels and sex, age, history of hypertension and diabetes mellitus, personal history of smoking and alcohol consumption and history of menopause in women