A One Year Cross-Sectional Study: To Study The Association Of Serum Gamma Glutamyl Transferase Levels With Metabolic Syndrome - Dr.Prabhakar Kore’s K.L.E.S Hospital, Belgaum

Abstract

Background and objectives Serum Gamma-glutamyl transferase level is a promising diagnostic marker for early detection of metabolic syndrome. It has also been shown to be an independent risk factor for the mortality and morbidity of cardiovascular diseases. The present study was aimed to find the association of serum gamma glutamyl transferase levels in patients with metabolic syndrome and to correlate serum gamma glutamyl transferase levels with the different components of metabolic syndrome. Methodology This one year study was conducted from January 2012 to December 2012 in the Department of Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum on a total of 100 patients with metabolic syndrome based on IDF criteria. Results In this study, 59% patients were males and 41% were females. The commonest age group was 41 to 50 years comprised of 42% of patients. There were no significant gender differences in GGT levels. History of diabetes was present in 65% of the patients and 55% had hypertension. Diabetic complications e.g. retinopathy was noted in 46% of the patients, and 44% of the patients had nephropathy. In this study, of the 63% patients presented with all the five metabolic syndrome components. Conclusion and interpretation Raised serum GGT levels were noted in 65% of the patients, while 35% of the patients had normal serum GGT levels. Among patients with all the five component abnormality, the mean serum GGT levels were significantly high (87.62 ± 17.57) (p<0.034). Serum GGT levels were comparable in both the sexes and in all the age groups. Raised serum GGT levels correlated well with hypertension and HDL, whereas no correlation was found between waist circumference and diabetes mellitus. Raised serum GGT levels also correlated well with glycaemic control (HbA1c), insulin resistance, and body mass index.