Association Of Serum Adiponectin Levels With Chronic Kidney Disease Stage 2 To Stage 4 In Patients With Type 2 Diabetes Mellitus - A One Year Cross-Sectional Study

Abstract

Background and objectives Adiponectin plays an important role in the pathogenesis of type 2 DM. In kidney disease, higher adiponectin levels are present in dialysis patients but not in nondiabetic patients with predialysis chronic kidney disease. The present study was aimed to find the association of serum adiponectin levels with stage 2 to stage 4 of Chronic Kidney Disease in patients with type 2 Diabetes mellitus. Methodology The present one year cross sectional study was done at Department of Nephrology/Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum. A total of 100 patients with type 2 diabetes mellitus and chronic kidney disease admitted during the study period from January 2012 to December 2012 were studied. Results In this study, maximum patients were in the age group of >60 years (53%) and the mean age was 64.4 ± 10.23 years. Of the 100 patients, 61% were males and 39% were females with male to female ratio of 1.56 to 1. The duration of diabetes was 6 to 10 years in 43% of the patients. Maximum number of patients were in the stage of II to III chronic kidney disease (86%) and 14% were in stage IV chronic kidney disease. In 26% of the patients, the adiponectin levels were below normal and in 5% they were more than normal. Conclusion and interpretation Advanced stage of the CKD in patients with T2DM was associated with low levels of adiponectin as higher number of patients with stage IV CKD (42.86%) had serum adiponectin levels ≤ 8.3 µg/mL. Low levels of serum adiponectin were also associated with age, gender, creatinine and proteinuria.