The Importance Of Serum Uric Acid Levels And Killip Classification In Predicting Prognosis Of Acute Myocardial Infarction

Abstract

Background and objectives: There is evidence that high uric acid is a negative prognostic marker in patients with mild to severe heart failure. Furthermore there is a need to find a simple, less expensive but accurate marker that could be useful in rural areas where fibrinolytic treatment is still the first choice of acute reperfusion therapy. Our study tried to correlate between serum uric acid levels and killip classification in predicting prognosis in acute myocardial infarction patients. . Methodology: The present one year cross-sectional study was done in the Department of Medicine and Cardiology, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum. A total of 100 acute myocardial infarction patients were included in the study. Patients were subjected to clinical examination, electrocardiogram and serum uric acid was measured on day 0, 3 and day 5. Serum uric acid levels and killip class of the patients were compared to assess the prognosis. Results: Majority of patients had abnormal uric acid on day 1.Patients with abnormal uric acid levels on all the 3 days were more in killip class III and IV as compared to class I and II. Among 18 patients who expired, 16 were in killip class III and IV (8 in each class).The mean serum uric acid levels of expired patients were raised on all the 3 days with maximum on day 1. Serum uric acid level was positively correlated with serum triglyceride level. Hyperuricemia was associated with left ventricle dysfunction. Conclusion and interpretation: Serum uric acid levels are raised in acute myocardial infarction patient. There is a positive correlation between rising serum uric acid levels with higher killip class. Combination of killip class and serum uric acid level after acute myocardial infarction is a good predictor of mortality. Hyperuricemia is positively correlated with serum triglyceride level and left ventricle dysfunction.