Association Of Mean Platelet Volume With Acute Ischemic Cerebrovascular Accident Among Patients With Type 2 Diabetes Mellitus - A Hospital Based Study

Abstract

Background and objectives It is reported that, MPV is raised in ischaemic stroke and type 2 diabetes mellitus respectively. Raise in MPV has shown poor outcome of stroke. This study aims at comparing the rise of MPV in diabetic and non diabetic cases with ischaemic stroke and assessing the outcome. Methodology This one year hospital based cross sectional study was carried out in the Department of Medicine. A total of 79 patients who presented with acute ischaemic stroke from January 2014 to December 2014 were enrolled (25 patients with diabetes and 54 non diabetics). All the patients underwent NIHSS at the time of admission and MPV was noted. Patients were evaluated for outcome based on MRM score. Results Majority of the diabetic (72%) and non diabetic (68.52%) patients were males (p=0.754). The mean age in diabetic patients was 62.04±10.88 years and in non diabetic patients it was 58.11±16.75 years (p=0.217). The commonest presentation was weakness in diabetic (96%) as well as in non diabetic patients (88.89%). History of previous stroke was present in 12% of the patients with DM compared to 1.85% of the non DM (p=0.091). The mean NIHSS scores were significantly high in patients with DM compared to non diabetic patients (20.38±3.19 vs 17.76±3.74; p=0.006). Majority of the patients with DM had raised MPV levels (>9.5) compared to non diabetic patients (72% vs 9.26%; p<0.001) and mean was also significantly high (10.16±0.89 vs 8.25±0.91;p<0.001) in respective subsets. Majority of the patients with DM had moderate to severe disability compared to non diabetic patients (68% vs 7.41%; p<0.001) and mean MRM scores were significantly high in diabetic population (4.12±0.66 vs 3.00±0.61; p<0.001). Conclusion and interpretation Acute ischaemic stroke in diabetic patients is significantly associated with raised MPV level which is likely to be severe with high morbidity and mortality.