Mean Platelet Volume In Patients Of Acute Coronary Syndromes In A Tertiary Care Hospital

Abstract

Background and objectives Platelet count and mean platelet volume being simple and reliable indicators of platelet size that correlates with platelet activation might be an emerging cardiovascular risk marker and potentially helpful in stratifying cardiovascular risk. Studying the correlation may help us to understand better and reduce the chance of myocardial infarction in the apparently healthy subjects Methodology The present one year cross-sectional study was done in the Department of Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi. A total of 400 Acute Coronary Syndromes patients were included in the study. Patients were subjected to clinical examination, electrocardiogram, platelet count and mean platelet volume. Results Majority of the patients were males (75.5%). The male to female ratio was 3.08:1. ‘p’ value for platelet count when compared between male and female was statistically significant.(p=0.001). In the present study majority of the patients were MI patients (75.75%). The MI patients to USA patients ratio was 3.123:1. The ‘p’ value for platelet count (p=0.99) and MPV(0.75) between the two groups was not significant. In the present study majority of the patients were non hypertensives (60.5%). Hypertensives to non hypertensives ratio was 1.53:1. MPV and Platelet counts were high in Hypertensives (8.927fl & 2.80 lacs) respectively. Hypertensives to non-hypertensives MPV and Platelet count ratio were 1.001 and 1.022 respectively which was not significant. In the present study majority of the patients were diabetics (60.5%). Diabetics to non diabetics ratio was 1.77:1, MPV and Platelet counts were high in Diabetics (8.979fl & 2.764 lacs) respectively. Diabetics to non-diabetics MPV and Platelet counts ratio were 1.010 and 1.001 respectively which was also not significant. In the present study majority of the patients were </=64 years(68.5%). Less than 65 years to more than 65 years ratio was 2.17:1. P value (p=0.011) was statistically significant for platelet count. In the present study majority of the patients(89%) were not on anti platelet therapy before admission. Ratio of patients not on anti platelet therapy to patients on anti platelet therapy before admission was 8.09:1with ‘p’ value 0.70 and 0.05 for MPV and platelet count respectively which was not statistically significant for MPV but significant for platelet count. In the present study majority of the patients were not thrombolysed (94.5%). Non thrombolysed to thrombolysed ratio was 17.18:1 with ‘p’ value of 0.13 and 0.19 for MPV and platelet count respectively. Conclusion and interpretation • The average values of MPV and platelet counts are 8.9+/-1.48 fl and 2.7+/-0.88 lacs in patients of acute coronary syndromes. • MPV and Platelet counts were high in Hypertensives and diabetics but was not statistically significant as compared to Non-hypertensives and non diabetics, which shows that MPV is an independent risk factor. • Platelet counts in patients of Acute Coronary Syndromes was higher in males as compared to that of females which was statistically significant. • The platelet count was higher in patients aged < 64 years as compared to patients who are > 65 years which was statistically significant.