Estimation Of Serum Testosterone Level And Its Co-Relation With Hematocrit In Type 2 Diabetes Male Patients - One Year Hospital Based Prospective Case-Control Study In KLES Dr Prabhakar Kore Charitable Hospital & MRC, Belgaum

Abstract

INTRODUCTION: Diabetes mellitus is heterogenous group of metabolic disorders. Hypogonadism is a clinical condition comprising both clinical and biochemical parameters of testosterone deficiency. Elder age and obesity both are linked with type 2 diabetes and both diminutions testosterone levels. Anaemia is frequently found in patients with diabetes, in whom it is associated with increased morbidity and mortality. Low testosterone levels are also common in men with type 2 diabetes. AIMS AND OBJECTIVES: AIMS: Estimation of Serum Testosterone level and its co-relation with Hematocrit in Type 2 diabetes male patients. OBJECTIVES: 1. To estimate the serum testosterone in type 2 diabetes mellitus. 2. To estimate anemia and hematocrit in type 2 diabetes mellitus. MATERIALS AND METHODS: A Prospective Case Control study, Patients presenting to departments of Internal medicine both inpatients and outpatients at KLES Dr Prabhakar Kore Charitable Hospital & MRC, Belgaum fulfilling the inclusion criteria. 75 diabetic cases and 75 age and BMI matched non diabetic controls were taken for study. RESULTS: In our study, we found 72% of diabetic cases had low tesotosterone, mean hematocrit value was 41.81%, in both cases and controls. Normocytic normochromic anemia was common finding. There was significant corelation between testosterone and hematocrit values, with p=0.000042. There was also significant corelation between duration of diabetes, BMI, regularity of treatment for diabetes with serum testosterone levels. CONCLUSION: These findings suggest that testosterone deficiency may contribute to the increased frequency of anaemia in men with type 2 diabetes. And low testosterone can be a predictor of insulin resistance and metabolic syndrome, further studies are needed for confirmation of low testosterone with coronary artery disease.