Correlation Of Plasma Fibrinogen Level In Type Ii Diabetes Mellitus Patients With Hba1c Levels And Microvascular Complications – A One Year Cross Sectional Study

Abstract

BACKGROUND: Diabetes is considered one of the most common non communicable diseases globally. There are various complications of diabetes mellitus which may be microvascular or macrovascular, affecting all the systems in the body. Many studies have shown that hemostatic disturbance, including high fibrinogen levels, are associated with coronary heart disease in patients with diabetes. AIMS AND OBJECTIVES: 1. To Study Plasma Fibrinogen levels in Type 2 Diabetes Mellitus patients with Microvascular complications. 2. To Study the association of Plasma Fibrinogen levels with Glycemic control. METHODOLOGY: A one year cross sectional study was conducted in the KLEs Dr.Prabhakar Kore Hospital and Medical Research Centre, Belagavi. 100 type 2 diabetes mellitus patients fulfilling the inclusion criteria were included in the study. These patients underwent history, clinical examination, FBS, PPBS, HBA1c and fibrinogen estimation. Descriptive statistics was used for data analysis. RESULTS: In our study, the prevalence of hyperfibrinogenemia was found to be 88%. There was a significant association between fibrinogen levels and HBA1c levels(p value less than 0.0001). We also found a significant association between duration of diabetes and fibrinogen levels(p value less han 0.001). There was no significant association between gender and HBA1c, HBA1c and microvascular complications and fibrinogen and microvascular complications. CONCLUSION: Thus plasma fibrinogen can be used as a marker for microvascular complications in type 2 diabetes mellitus as the prevalence of hyperfibrinogenemia among type2 diabetes patients with microvascular complications was 88%. There was also a significant association between duration of diabetes and plasma fibrinogen and glycaemic control and plasma fibrinogen.