The Relationship Between Glycosylated Hemoglobin and Mean Platelet Volume in Type 2 Diabetes Mellitus Patients – A one Year Cross Sectional Hospital Based Study At KLES Dr Prabhakar Kore Hospital, Belagavi.

Abstract

Background and objectives ABSTRACT Mean Platelet volume ( MPV ) being a determinant of platelet functionality. Increased MPV levels are associated with increased risk for hyperglycemic complications. The present study was aimed to find the relationship between glycosylated hemoglobin ( HbA1c ) and MPV in patients with type 2 diabetes mellitus ( T2DM) . Methodology This one year hospital based cross sectional study was conducted in the Department of General Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi from January 2017 to December 2017. A total of 100 patients presenting with T2DM, fulfilling the selection criteria were studied. The selected patients evaluated for HbA1c, MPV, fasting blood sugar ( FBS ) and other relevant tests. Results The male to female ratio was 1:1.04 and 51% of the patients were females. The common age group was 51 to 60 years and 61 to 70 years ( 30% each) . The mean age was 55.83±10.84 years. The mean duration of diabetes was 5.94±5.03 years and most of the patients ( 45% ) reported duration of diabetes between one to five years. Treatment with oral hypoglycaemic agents was reported by 43% of the patients. Majority of the patients ( 74% ) reported good treatment compliance Most of the patients had ( 61% ) microvascular complications and abnormal fundoscopy was noted in 81% of the patients and 55% of the patients had abnormal ECG findings. 48% of VI the patients had MPV levels between 7.01 to 9.00 fL and 42% of the patients had MPV levels between 9.01 to 11.00 the mean MPV levels were noted as 9.08±1.20 fL. HbA1c of ≤7.0 percent was noted in 23% of the patients and 77% of the patients had HbA1c levels of > 7.00 percent. The mean HbA1c levels were noted as 9.86±3.02 percent. All the patients with MPV of > 11 had HbA1c levels of > 7 percent and all the patients with MPV of < 7 had HbA1c levels of ≤7 percent. ( p=0.002 ) . The mean MPV levels in patients with HbA1c levels of ≤ 7 percent were significantly low compared to those with HbA1c of >7 percent ( 8.33±1.09 fL vs 9.4±0.92; p<0.001) . There was significant weak positive correlation between MPV and HbA1c ( r=0.287; R 2 =0.0823; p=0.004) . Conclusion and interpretation Based on the findings of this study it may be concluded that, There is strong association and relationship between HbA1c and MPV in patients with type 2 diabetes mellitus.