Study of Clinical Profile of Patients of Non Alcoholic Fatty Liver Disease and its Association with Metabolic Syndrome

Abstract

BACKGROUND AND OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is considered to be the commonest liver problem in the western world and is increasingly being recognized as a major cause of liver-related morbidity and mortality. It is known to be associated with various metabolic abnormalities, but not much information regarding association between the metabolic disease and the severity of fatty liver is available. METHODS: 100 consecutive patients aged >18 years attending the outpatient and inpatient of department of medicine, Jawaharlal Nehru medical college and hospital from January 2017-18, were included according to the inclusion and exclusion criteria. Relevant clinical, anthropometric, biochemical and radiological data was recorded. The study was an observational and analytical study of patients diagnosed as NAFLD. All patients diagnosed as NAFLD were investigated for metabolic syndrome according to the NCEP ATP 3 criteria and a relationship between NAFLD and metabolic syndrome was studied. RESULTS: 53% of patients of NAFLD had metabolic syndrome and statistical significance was found in waist circumference, blood pressure, triglycerides and fasting glucose. CONCLUSION: There is higher prevalence of all the components of metabolic syndrome in cases of NAFLD. Its early detection will help in modifying the disease course, delaying complications and will also play a major role in preventive cardiology.