Ultrasound Guided Intra Uterine Insemination – A Randomized Clinical Trial

Abstract

Background and objective ABSTRACT Approximately 8 to 10% of couples remain childless against the wishes of the partners showing that infertility is a common problem. The objective of the present study was to compare the efficacy of ultrasound ( USG ) guided IUI versus conventional IUI on pregnancy rate. Methodology The present randomized clinical trial was conducted at Assisted Reproduction Centre, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum during the period of October 2008 to December 2009. A total of 897 women were included in the study fulfilling the selection criteria. Ovulation induction was done as per the protocol and after randomizing patient IUI was done with or without ultrasound guidance. Pregnancy rates in USG guided IUI and in conventional method IUI were recorded. Results In this study out of 897 patients, follow-up was lost in 72 patients hence a total of 825 patients were studied of which 37.82% of patients were in the age group between 25 to 29 years and 38.79% had single cycle IUI. 64.12% patients had AIH insemination and 35.88% had AID insemination. After randomization, 51.27% patients were in conventional group and 48.73% in USG guided group. The overall success rate of study was 7.88%. Age did not have any significant effect on the pregnancy outcome except for the age group between 25 to 29 years ( 12.84% ) ( p=0.048 ) . The success rate using ultrasound was significantly higher IV ( 10.44% ) compared to conventional method ( 5.43% ) ( p=0.007 ) . On further analysis in AID group, 14.48% conceived with USG guided IUI compared to 7.28% with conventional method of IUI ( p=0.046) . Conclusion IUI performed under ultrasound guidance and insemination with donor sample improves the pregnancy rate.