Biochemical changes in individuals of High bmi with special reference to Medho sara (excellence of adipose Tissue) and sthaulya (obesity) See

ABSTRACT Biochemical Changes in Individuals of High BMI with special reference to Medho Sara (Excellence of Adipose Tissue) and Sthaulya (Obesity) Background: Obesity, or Sthaulya, is a major public health issue, especially in India, where the swift epidemiological change has increased obesity-related ailments. Traditional Ayurvedic principles, such as Medho Sara (the superiority of adipose tissue), offer a foundation for comprehending the physiological and pathological conditi...

Efficacy of integrated ayurveda treatment Protocol in uncontrolled type 2 diabetes Mellitus-a randomised controlled clinical trial See

1.1 ABSTRACT Introduction: Type 2 Diabetes Mellitus (T2DM) is a metabolic condition characterized by insulin resistance and pancreatic β-cell dysfunction caused by uncontrolled hyperglycaemia. There is also a link of inflammation in the pathogenesis of T2DM. T2DM is a growing concern worldwide, having reached epidemic proportions in many developing and most developed countries. According to American Diabetes Association, uncontrolled T2DM is measured as a glycated hemoglobin lev...

Assessment and Evaluation of Rational Dispensing of Topical Corticosteroids by Community Pharmacists and It's Implication on Health Science Population See

ABSTRACT Introduction and background: Topical corticosteroids abuse is quite common with varied presentations, most commonly on face is an increasing problem encountered by dermatologists in India. Lack of public awareness and the ease of obtaining topical corticosteroids without a prescription are important underlying factors. There is a need to take urgent remedial steps and increase awareness about this problem in Community Pharmacist, Health Sciences Student Population and Pat...

Synthesis, characterization, in-silico study and Antidiabetic evaluation of nitrogen and sulphur Containing heterocyclic analogues See

ABSTRACT Background: India, often referred to as the diabetic capital of the world, faces limitations in existing oral antidiabetic drug efficacy. Nitrogen and sulphur-containing heterocycles are potential for managing T2DM by targeting specific biological targets. Objectives: The study employed to design, synthesis and characterize novel nitrogen and sulphur-containing heterocycles, and explore their molecular mechanisms for antidiabetic activity.

In silico docking based pharmacological Screening for the hepatoprotective activity Of cucumis melo and cucurbita pepo in Experimental animals. See

ABSTRACT Background: Cucumis melo and Cucurbita pepo widely utilized vegetable fruit and traditionally claimed for hepatoprotective activity. However, their hepatoprotective molecular mechanisms are not yet elucidated. The current study utilized multiple in silico approaches to identify the mechanisms of action of bioactive phytocompounds of C. melo and C. pepo and potential targets of liver cirrhosis, validated through cytotoxic and hepatoprotective effect of both the herbs in He...

Determinants and consequences Of post-stroke disabilities- A hospital-based study See

ABSTRACT Background: Stroke is a major public health problem in India with an increase in the prevalence of post-stroke disabilities. There is a lack of studies on the determinants and consequences of stroke in India. Objective: To study the determinants of post-stroke disabilities and their consequences in terms of caregiver burden, family needs, coping strategies and quality of life.

Effectiveness of counselling by clinical Pharmacist on medication adherence in epileptic Children at tertiary care hospital: A randomized controlled study See

ABSTRACT Introduction: This study aimed to evaluate the impact of a structured intervention on medication adherence among epilepsy patients. Medication adherence is crucial for managing epilepsy effectively, yet non-compliance remains a significant challenge. The structured intervention included patient counselling, information leaflets, and other support measures to manage adverse effects and improve adherence. The study also aimed to assess the impact of this intervention on qua...

High-intensity interval training versus hatha Yoga for postmenopausal women with central Obesity, sarcopenia, and dynapenia on muscle And fat mass, abdominal fat and lower limb Alignment: a randomized clinical trial See

ABSTRACT Background: Menopause is a demanding phase in a woman’s life, often accompanied by a rise in musculoskeletal concerns and obesity, requiring early and effective intervention. The influence of High-Intensity Interval Training (HIIT) and Hatha yoga on musculoskeletal health in postmenopausal women remains inadequately studied. While both exercise methods have distinct characteristics, they also share notable differences and similarities. Aims: To assess and compare the e...

Screening and development of antimalarial and Antifilarial drugs of herbal origin through targetbased Drug Development Approach See

Background: Among vector-borne diseases malaria affects nearly half of the world's population, as estimated by the WHO in 2022, and the disease was responsible for over 249 million people in 85 countries. Another global vector-borne threat is lymphatic filariasis that affects 859 million people in 50 countries, causing long lasting and severe morbidity. However, currently, while antimalarial campaigns are facing the problem of drug resistance, antifilarial programmes are facing the ...

Growth velocity and its association With diet among under five children Residing in rural area of belagavi-a Longitudinal study See

ABSTRACT Background Growth and development are unique features in children. Child grows continuously till the adulthood. There are periods of rapid growth and slower growth in every child but the pattern of growth differs in children depending on various factors ranging from genetics to environment, socio demography. Nutrition plays an important role in maintaining growth of children. Objectives Primary Objective: 1. Assessment of growth velocity among children aged betwee...

Formulation, Optimization And Characterization Of Fisetin Loaded Cubosomes For The Treatment Of Lung Cancer: An Experimental Study See

ABSTRACT Background Lung cancer is reported very commonly in all the diagnosed human cancer types with the highest death rate. It is treated with surgical resection, radiation, and chemotherapy but it has many adverse effects, toxicity, drug resistance and disease recurrence. Many effective anticancer drugs are used in the treatment but there is a need to improve the therapeutic potential of existing and development of new anticancer drugs. Phytoconstituents are effective and ha...

Development and validation of newer Analytical techniques for selected non Steroidal anti-inflammatory drugs See

ABSTRACT Background: The increasing complexity of pharmaceutical formulations necessitates precise and robust analytical methods to ensure quality, safety, and efficacy. Loxoprofen sodium, Baclofen, Etodolac, and Thiocolchicoside possess anti- inflammatory, muscle relaxant, and analgesic properties. However, their simultaneous quantitative estimation in formulations poses significant challenges. This study addresses the need for advanced UV-spectrometric and chromatographic methods...

Vaginal micro biome and socio demographic determinants of spontaneous abortion in a tertiary care hospitals of north karnataka See

ABSTRACT Background:. Spontaneous abortion (SA) is the termination of a pregnancy without medical or mechanical intervention before the fetus is sufficiently developed to survive. In other words, miscarriage is early pregnancy loss before 20th week of gestation, or 139 days, counting from the first day of the last normal menses. At least 15-20% of pregnancies that are clinically detected end in spontaneous abortion in the first trimester. First trimester, or the first three months of pregna...

Exploration of clinical trial stakeholders perspectives towards genetic research data for future use See

ABSTRACT Introduction: Adhering to Good Clinical Practice (GCP) guidelines, it is essential that personnel engaged in clinical trials and genetic research are adequately educated and trained. Clinical trial investigators bear the responsibility to protect participant privacy and prevent the unauthorized reuse of research data. Aim: This study aims to evaluate the knowledge, attitudes, and practices (KAP) of clinical trial stakeholders regarding the reuse of genetic data for future research.

Bioactivity guided isolation and formulation of Natural pesticides against three different Mosquito species See

ABSTRACT BACKGROUND: Mosquitoes transmit viruses and parasites, which increase human mortality. Various methods are being adopted to control mosquitoes involving the use of synthetic pesticides with unexpected consequences on both target and non-target organisms. As substitutes for synthetics, natural products with agronomic qualities of biodegradability, low resistance, and those preserving ecological equilibrium are to be preferred. OBJECTIVE: To identify active extracts, isolate pes...

Development and evaluation of diacerein and aceclofenac loaded topical nanoemulgel for osteoarthritis an experimental study See

ABSTRACT Background Osteoarthritis (OA) affects millions globally, causing chronic pain and disability. Current oral therapies, like nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 enzyme inhibitors, have limited effectiveness and significant side effects. Nowadays, the focus of OA treatment has shifted towards modifying and slowing disease progression along with symptomatic management. Diacerein (DCN) and aceclofenac (ACE), frequently prescribed for OA treatment due to their dise...

Evaluation of potentiated yashada bhasma for safety bioavailability and spermatogenic activity See

ABSTRACT Background: Bhasma, traditional Ayurvedic formulation, are renowned for their nanoscale dimensions and superior bioavailability. Yashada bhasma, a zinc-based preparation, has demonstrated therapeutic potential, particularly in enhancing male fertility and spermatogenesis. Zinc’s pivotal role in sperm motility, morphology, and spermatogenesis underscores the importance of optimizing Yashada bhasma preparation through modern techniques to enhance its efficacy. Objectives: 1. To pote...

Effectiveness of structured training program stp on provider perspectives regarding respectful maternity care in maternity units of selected tertiary care hospital belagavi See

ABSTRACT Background: Pregnancy is a unique, exciting, and often happy time in a woman's life, emphasizing the incredible creative and caring process. Complications can occur at any stage of pregnancy. So, timely obstetric care services are vital for addressing difficulties during pregnancy, labour, and the immediate postpartum period. The National Health Mission (NHM) has implemented numerous measures to reduce maternal and new-born mortality in India. One of the key initiatives is LaQshya, ...

Exploring Ethanolic Extract Of Alpinia Calcarata Roscoe Rhizome For Its Peripheral Neuroprotective Activity In Wistar Rats See

xxi ABSTRACT Alpinia calcarata Roscoe (ACR) is a member of the Zingiberaceae family, and its rhizome contains bioactive compounds such as flavonoids and terpenoids, as well as phenolic compounds with antioxidant, anti-inflammatory, antidiabetic, antifungal, antibacterial, analgesic, and anticancer properties. This study explores the neuroprotective potential of the Ethanolic Extract of Alpinia calcarata Roscoe (EEAC) using Wistar albino rat models of peripheral neuropathy. HPLC analysis con...